发明授权
US08178727B2 Bis(arylmethylidene)acetone compound, anti-cancer agent, carcinogenesis-preventive agent, inhibitor of expression of Ki-Ras, ErbB2, c-Myc and Cycline D1, β-catenin-degrading agent, and p53 expression enhancer
有权
双（芳基亚甲基）丙酮化合物，抗癌剂，致癌作用预防剂，Ki-Ras，ErbB2，c-Myc和Cycline D1，b-cadherin降解剂和p53表达增强子表达抑制剂
- 专利标题： Bis(arylmethylidene)acetone compound, anti-cancer agent, carcinogenesis-preventive agent, inhibitor of expression of Ki-Ras, ErbB2, c-Myc and Cycline D1, β-catenin-degrading agent, and p53 expression enhancer
- 专利标题（中）： 双（芳基亚甲基）丙酮化合物，抗癌剂，致癌作用预防剂，Ki-Ras，ErbB2，c-Myc和Cycline D1，b-cadherin降解剂和p53表达增强子表达抑制剂
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申请号： US11993840申请日： 2006-06-27
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公开(公告)号： US08178727B2公开(公告)日： 2012-05-15
- 发明人: Hiroyuki Shibata , Yoshiharu Iwabuchi , Hisatsugu Ohori , Hiroyuki Yamakoshi , Yuichi Kakudo
- 申请人： Hiroyuki Shibata , Yoshiharu Iwabuchi , Hisatsugu Ohori , Hiroyuki Yamakoshi , Yuichi Kakudo
- 申请人地址： JP
- 专利权人： National University Corporation Tohoku University
- 当前专利权人： National University Corporation Tohoku University
- 当前专利权人地址： JP
- 代理机构： Hayes Soloway P.C.
- 优先权： JP2005-187394 20050627
- 国际申请： PCT/JP2006/312806 WO 20060627
- 国际公布： WO2007/000998 WO 20070104
- 主分类号： C07C49/217
- IPC分类号： C07C49/217 ; A61K31/12
摘要：
It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.
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