Invention Grant
US08178667B2 Benzyl-substituted quinolone M1 receptor positive allosteric modulators
有权
苄基取代喹诺酮M1受体阳性变构调节剂
- Patent Title: Benzyl-substituted quinolone M1 receptor positive allosteric modulators
- Patent Title (中): 苄基取代喹诺酮M1受体阳性变构调节剂
-
Application No.: US12308929Application Date: 2007-06-27
-
Publication No.: US08178667B2Publication Date: 2012-05-15
- Inventor: Craig Lindsley , William D. Shipe , Feng Yang , Jaime Lynn Bunda
- Applicant: Craig Lindsley , William D. Shipe , Feng Yang , Jaime Lynn Bunda
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; Gerard M. Devlin
- International Application: PCT/US2007/014943 WO 20070627
- International Announcement: WO2008/002621 WO 20080103
- Main IPC: C07D401/10
- IPC: C07D401/10 ; C07D401/14 ; C07D413/14
Abstract:
The present invention is directed to benzyl-substituted quinolone compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of diseases in which the M1 receptor is involved.
Public/Granted literature
- US20100009962A1 Benzyl-substituted quinolone m1 receptor positive allosteric modulators Public/Granted day:2010-01-14
Information query
