Quantum and digital processors are employed together to solve computational problems. The quantum processor may be configured with a problem via a problem Hamiltonian and operated to perform adiabatic quantum computation and/or quantum annealing on the problem Hamiltonian to return a first solution to the problem that is in the neighborhood of the global minimum of the problem Hamiltonian. The digital processor may then be used to refine the first solution to the problem by casting the first solution to the problem as a starting point for a classical optimization algorithm. The classical optimization algorithm may return a second solution to the problem that corresponds to a lower energy state in the neighborhood of the global minimum, such as a ground state of the problem Hamiltonian. The quantum processor may include a superconducting quantum processor implementing superconducting flux qubits.