A multi-modality imaging system includes a first imaging system and a second imaging system that is different from the first imaging system. The first and second imaging systems are slidingly mounted on at least one rail. A table has a movable pallet configured to extend through a scan range of the first imaging system while the first and second imaging systems are positioned proximate each other at one position along the at least one rail. The pallet is further configured to extend through a scan range of the second imaging system while the first and second imaging systems are positioned proximate each other at a different position along the at least one rail. At least a portion of the scan ranges overlap each other.