Invention Grant
- Patent Title: Tetrahydro-naphthalene derivatives
- Patent Title (中): 四氢萘衍生物
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Application No.: US13052482Application Date: 2011-03-21
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Publication No.: US08173841B2Publication Date: 2012-05-08
- Inventor: Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
- Applicant: Masaomi Tajimi , Toshio Kokubo , Masahiro Shiroo , Yasuhiro Tsukimi , Takeshi Yura , Klaus Urbahns , Noriyuki Yamamoto , Muneto Mogi , Hiroshi Fujishima , Tsutomu Masuda , Nagahiro Yoshida , Toshiya Moriwaki
- Applicant Address: GB Cambridgeshire
- Assignee: Xention Limited
- Current Assignee: Xention Limited
- Current Assignee Address: GB Cambridgeshire
- Agency: Baker Botts LLP
- Main IPC: C07C273/00
- IPC: C07C273/00 ; A61K31/17
Abstract:
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontinence, chronic pain, neuropathic pain, post-operative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
Public/Granted literature
- US20110178088A1 TETRAHYDRO-NAPHTHALENE DERIVATIVES Public/Granted day:2011-07-21
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