Invention Grant
US08173770B2 Intermediates for LHRH antagonist synthesis, process for the production, and process for LHRH antagonist production
有权
LHRH拮抗剂合成的中间体，生产过程和LHRH拮抗剂生产过程
- Patent Title: Intermediates for LHRH antagonist synthesis, process for the production, and process for LHRH antagonist production
- Patent Title (中): LHRH拮抗剂合成的中间体，生产过程和LHRH拮抗剂生产过程
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Application No.: US12189925Application Date: 2008-08-12
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Publication No.: US08173770B2Publication Date: 2012-05-08
- Inventor: Jon H. Rasmussen , Palle H. Rasmussen , Wolfgang O. Wachs , Stefan Hansen , Jens Fomsgaard
- Applicant: Jon H. Rasmussen , Palle H. Rasmussen , Wolfgang O. Wachs , Stefan Hansen , Jens Fomsgaard
- Applicant Address: DK Hilleröd
- Assignee: Polypeptide Laboratories A/S
- Current Assignee: Polypeptide Laboratories A/S
- Current Assignee Address: DK Hilleröd
- Agency: Dickstein Shapiro LLP
- Priority: SE0104463 20011229
- Main IPC: A61K38/06
- IPC: A61K38/06 ; A61K38/08 ; A61K38/24 ; C07K1/06
Abstract:
The peptides Ac-D-2Nal-D-4ClPhe-D-3Pal-OH and Boc-D-2Nal-D-4ClPhe-D-3Pal-OH are intermediates useful in the synthesis of LHRH analogs by coupling with suitable heptapeptides, in particular with the heptapeptides P1-Ser(P2)-MMeTry(P3)-D-Lys(Nic)-Leu-Lys(iPr,P4)-Pro-D-AlaNH2 and P1-Ser(P2)-NMeTry(P3)-D-Asn-Leu-Lys(iPr,P4)-Pro-D-AlaNH2.
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