Invention Grant
US08173682B2 Substituted pyridones as inhibitors of poly(ADP-ribose) polymerase (PARP)
有权
取代的吡啶酮作为聚（ADP-核糖）聚合酶（PARP）的抑制剂
- Patent Title: Substituted pyridones as inhibitors of poly(ADP-ribose) polymerase (PARP)
- Patent Title (中): 取代的吡啶酮作为聚（ADP-核糖）聚合酶（PARP）的抑制剂
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Application No.: US11535127Application Date: 2006-09-26
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Publication No.: US08173682B2Publication Date: 2012-05-08
- Inventor: Philip M. Weintraub , Paul R. Eastwood , Shujaath Mehdi , David W. Stefany , Kwon Yon Musick , Neil Moorcroft , Sungtaek Lim , John Z. Jiang , Hartmut Rutten , Stefan Peukert , Uwe Schwahn
- Applicant: Philip M. Weintraub , Paul R. Eastwood , Shujaath Mehdi , David W. Stefany , Kwon Yon Musick , Neil Moorcroft , Sungtaek Lim , John Z. Jiang , Hartmut Rutten , Stefan Peukert , Uwe Schwahn
- Applicant Address: US NJ Bridgewater
- Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee Address: US NJ Bridgewater
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Main IPC: A61K31/4436
- IPC: A61K31/4436 ; C07D401/14
Abstract:
The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
Public/Granted literature
- US20070032489A1 SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) Public/Granted day:2007-02-08
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