Certain embodiments of the present invention provide a system for analyzing a treatment of a patent including: an interactive image editor for allowing a user to interact with a first set image data corresponding to a pre-treatment radiological study of a patient, the first set of image data including an untreated clinical area of interest, such that the user is capable of interacting with the first set of image data to form a target outcome image for the clinical area of interest; a criterion determination module for allowing the user to determine a target outcome criterion; processing module for performing a comparison by comparing the first set of image data with a second set of image data corresponding to a post-treatment radiological study of the patient, the second set of image data including a treated clinical area of interest; and a criterion evaluation module for automatically evaluating the comparison to determine a post-treatment effect. In an embodiment, the criterion evaluation module is further for evaluating automatically a treatment effectiveness evaluation based on an extent to which the post-treatment effect satisfies the target outcome criterion.