A machine-implemented system and method are described for removing interference between adjacent distributed-input-distributed-output (DIDO) clusters comprising. For example, a method according to one embodiment comprises: detecting signal strength at a first client from a main DIDO cluster; detecting interference signal strength at the first client from an interfering DIDO cluster; if the signal strength from the main DIDO cluster reaches a specified value relative to the value of the interference signal strength from the interfering DIDO cluster, then generating channel state information (CSI) defining channel state between one or more antennas of the first client and one or more antennas of the interfering DIDO cluster; transmitting the CSI from the first client to a base transceiver station (BTS) in the interfering DIDO cluster; and implementing DIDO precoding with inter-DIDO-cluster interference (IDCI) cancellation at the BTS in the interfering DIDO cluster to avoid RF interference at the first client.