Methods for inter-mixer communication enable a “self-formed” cascaded mixer node tree topology. One method enables inter-mixer node signaling and includes first selecting a plurality of media flow payloads at a first cascaded mixer node. A set of conference payloads are generated and each include the media flow payloads from the plurality of media flow payloads that are part of the same conference call, an identifier for the conference call, and a node identifier for each media flow in the conference call. For each media flow in the conference call, each conference payload further identifies whether the first cascaded mixer node is a root node or a leaf node. The set of conference payloads are bundled into a single packet and sent to a second cascaded mixer node. Another method enables the “self-forming” of the mixer node tree topology. Yet another method enables active talker identification within the “self-formed” tree topology.