Dome-loaded pressure regulators are disclosed. An example pressure regulator includes a body having a pressure inlet and first and second pressure outlets and a first dome-loaded pressure regulating valve fluidly coupled to the pressure inlet, the first pressure outlet, and a first control pressure. The first dome-loaded pressure regulating valve includes a first piston having a transverse bore defining a fluid path through the first piston to fluidly couple the pressure inlet to the first pressure outlet and configured to engage a first valve seat and to respond to the first control pressure to control the flow of fluid between the pressure inlet and the first pressure outlet via the first valve seat. The example pressure regulator includes a second dome-loaded pressure regulating valve fluidly coupled to the pressure inlet, the second pressure outlet, and a second control pressure.