发明授权
US08163800B2 PKC-activating compounds for the treatment of neurodegenerative diseases
有权
用于治疗神经变性疾病的PKC活化化合物
- 专利标题： PKC-activating compounds for the treatment of neurodegenerative diseases
- 专利标题（中）： 用于治疗神经变性疾病的PKC活化化合物
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申请号： US12510681申请日： 2009-07-28
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公开(公告)号： US08163800B2公开(公告)日： 2012-04-24
- 发明人: Thomas J. Nelson , Daniel L. Alkon
- 申请人： Thomas J. Nelson , Daniel L. Alkon
- 申请人地址： US WV Morgantown
- 专利权人： Blanchette Rockefeller Neurosciences Institute
- 当前专利权人： Blanchette Rockefeller Neurosciences Institute
- 当前专利权人地址： US WV Morgantown
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 主分类号： A61K31/19
- IPC分类号： A61K31/19 ; A61K31/20
摘要：
The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.
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