Invention Grant
US08158783B2 MTP inhibiting tetrahydro-naphthalene-1-carboxylic acid derivatives
有权
MTP抑制四氢 - 萘-1-羧酸衍生物
- Patent Title: MTP inhibiting tetrahydro-naphthalene-1-carboxylic acid derivatives
- Patent Title (中): MTP抑制四氢 - 萘-1-羧酸衍生物
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Application No.: US12446581Application Date: 2007-10-22
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Publication No.: US08158783B2Publication Date: 2012-04-17
- Inventor: Lieven Meerpoel , Leo Jacobus Jozef Backx , Peter Ten Holte , Guuske Frederike Busscher
- Applicant: Lieven Meerpoel , Leo Jacobus Jozef Backx , Peter Ten Holte , Guuske Frederike Busscher
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica N.V.
- Current Assignee: Janssen Pharmaceutica N.V.
- Current Assignee Address: BE Beerse
- Priority: EP06122820 20061024
- International Application: PCT/EP2007/061289 WO 20071022
- International Announcement: WO2008/049808 WO 20080502
- Main IPC: A61K31/55
- IPC: A61K31/55 ; A61K31/4439 ; A61K31/165 ; A61K31/5377 ; C07D223/12 ; C07D401/12 ; C07D413/12 ; C07C233/00
Abstract:
The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes. Formula (I).
Public/Granted literature
- US20100016291A1 MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES Public/Granted day:2010-01-21
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