发明授权
US08153677B2 Substituted pyrazolylamide compounds useful as glucokinase activators
有权
用作葡糖激酶活化剂的取代的吡唑基酰胺化合物
- 专利标题： Substituted pyrazolylamide compounds useful as glucokinase activators
- 专利标题（中）： 用作葡糖激酶活化剂的取代的吡唑基酰胺化合物
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申请号： US13012351申请日： 2011-01-24
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公开(公告)号： US08153677B2公开(公告)日： 2012-04-10
- 发明人: Denis E. Ryono , Peter T. W. Cheng , Scott A. Bolton , Sean Chen , Yan Shi , Wei Meng , Joseph A. Tino , Richard B. Sulsky
- 申请人： Denis E. Ryono , Peter T. W. Cheng , Scott A. Bolton , Sean Chen , Yan Shi , Wei Meng , Joseph A. Tino , Richard B. Sulsky
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Gary D. Greenblatt
- 主分类号： A61K31/415
- IPC分类号： A61K31/415
摘要：
Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n—Z—(CH2)m—PO(OR7)(OR8), —(CH2)nZ—(CH2)m—OPO(OR7)R9, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from hydrogen, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
公开/授权文献
- US20110118211A1 NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME 公开/授权日：2011-05-19
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