Disclosed is a method and an apparatus for subchannel assignment for suppressing inter-antenna interference in an Orthogonal Frequency Division Multiplexing Access (OFDMA) system based distributed wireless communication system equipped with antennas that are randomly distributed in a geographical manner and can simultaneously communicate with multiple Subscriber Stations (SSs). The method includes selecting and obtaining access to distributed antennas which satisfy the data transmission rate that an SS requires and with which the SS can communicate; re-queuing a distributed antenna having the maximum transmitted power within the same cell in high priority; and assigning subchannels to the relevant distributed antennas in an order from the relevant distributed antenna having the high priority.