发明授权
- 专利标题： Rhodanine derivatives, a process for the preparation thereof and pharmaceutical composition containing the same
- 专利标题（中）： 罗丹宁衍生物，其制备方法和含有它们的药物组合物
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申请号： US12087474申请日： 2006-12-08
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公开(公告)号： US08148541B2公开(公告)日： 2012-04-03
- 发明人: Seong Eon Ryu , Seung Jun Kim , Dae Gwin Jeong , Sang Hyeup Lee , Suk Kyeong Jung , Hwan Mook Kim , Song Kyu Park , Ki Ho Lee , Chang Woo Lee , Joong-Kwon Choi , Jin Hee Ahn
- 申请人： Seong Eon Ryu , Seung Jun Kim , Dae Gwin Jeong , Sang Hyeup Lee , Suk Kyeong Jung , Hwan Mook Kim , Song Kyu Park , Ki Ho Lee , Chang Woo Lee , Joong-Kwon Choi , Jin Hee Ahn
- 申请人地址： KR Taejeon-Si
- 专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址： KR Taejeon-Si
- 代理机构： The Nath Law Group
- 代理商 Tanya E. Harkins; Mihsuhn Koh
- 优先权： KR10-2006-0002175 20060109
- 国际申请： PCT/KR2006/005343 WO 20061208
- 国际公布： WO2007/081091 WO 20070719
- 主分类号： C07D277/04
- IPC分类号： C07D277/04 ; C07D417/02 ; C07D413/02 ; A61K31/535 ; A61K31/497 ; A61K31/425
摘要：
Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.
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