A microfluidic bubble fuse is formed from a hermetically sealed reservoir containing an electrically conductive liquid. The reservoir is interposed between a pair of electrodes such that each electrode is in electrical contact with the fluid within the reservoir, and such that the fluid within the reservoir provides electrical interconnectivity between the electrodes. The reservoir may be implemented on a substrate, in a tube, or in another manner. When the current or voltage across the electrodes increases beyond a threshold, the excess current or voltage will cause a bubble to be created within the fluid to reduce or inhibit the flow of electricity between the electrodes. When the current/voltage is reduced, the bubble will collapse to restore the flow of electricity between the electrodes.