Invention Grant
US08133724B2 Human androgen receptor alternative splice variants as biomarkers and therapeutic targets
有权
人类雄激素受体替代剪接变体作为生物标志物和治疗靶标
- Patent Title: Human androgen receptor alternative splice variants as biomarkers and therapeutic targets
- Patent Title (中): 人类雄激素受体替代剪接变体作为生物标志物和治疗靶标
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Application No.: US12562031Application Date: 2009-09-17
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Publication No.: US08133724B2Publication Date: 2012-03-13
- Inventor: Yun Qiu , Zhiyong Guo , Xi Yang
- Applicant: Yun Qiu , Zhiyong Guo , Xi Yang
- Applicant Address: US MD Baltimore
- Assignee: University of Maryland, Baltimore
- Current Assignee: University of Maryland, Baltimore
- Current Assignee Address: US MD Baltimore
- Agency: Roylance, Abrams, Berdo & Goodman LLP
- Main IPC: C07K14/72
- IPC: C07K14/72 ; C12N5/10 ; C12N15/12
Abstract:
The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate cancer based on these novel androgen receptor splice variants, as well as methods for screening agents which modulate the activity and/or expression of the androgen receptor splice variants. Vectors, host cells and recombinant methods for producing the same and transgenic animals are also provided.
Public/Granted literature
- US20100068802A1 NOVEL HUMAN ANDROGEN RECEPTOR ALTERNATIVE SPLICE VARIANTS AS BIOMARKERS AND THERAPEUTIC TARGETS Public/Granted day:2010-03-18
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