Invention Grant
- Patent Title: Preparation of opiate analgesics by reductive alkylation
- Patent Title (中): 通过还原烷基化制备鸦片止痛药
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Application No.: US11628210Application Date: 2005-09-14
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Publication No.: US08119803B2Publication Date: 2012-02-21
- Inventor: Melville Mitchell , Neil Kenneth Thomson , George Scott Wilson , Neil John Goodwin , Maureen Joan Young
- Applicant: Melville Mitchell , Neil Kenneth Thomson , George Scott Wilson , Neil John Goodwin , Maureen Joan Young
- Applicant Address: GB London
- Assignee: Johnson Matthey Public Limited Company
- Current Assignee: Johnson Matthey Public Limited Company
- Current Assignee Address: GB London
- Agency: RatnerPrestia
- Priority: GB0421687.5 20040930
- International Application: PCT/GB2005/003547 WO 20050914
- International Announcement: WO2006/035195 WO 20060406
- Main IPC: C07D489/02
- IPC: C07D489/02 ; C07D489/08

Abstract:
A process for preparing a compound of formula (A), (B) or (C): wherein P is H, CH3 or a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH3)2OH, (CH3)(C(CH3)3)OH or COCH3; Z is C2-C10 alkyl or C2-C10 arylalkyl; and is a single bond or a double bond, is disclosed. The process includes reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst.
Public/Granted literature
- US20080045715A1 Preparation of Opiate Analgesics by Reductive Alkylation Public/Granted day:2008-02-21
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