发明授权
US08119665B2 Aryl imidazoles and related compounds as C5a receptor modulators
失效
芳基咪唑和相关化合物作为C5a受体调节剂
- 专利标题： Aryl imidazoles and related compounds as C5a receptor modulators
- 专利标题（中）： 芳基咪唑和相关化合物作为C5a受体调节剂
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申请号： US11680865申请日： 2007-03-01
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公开(公告)号： US08119665B2公开(公告)日： 2012-02-21
- 发明人: George P. Luke , George D. Maynard , Scott Mitchell , Andrew Thurkauf , Linghong Xie , LuYan Zhang , Suoming Zhang , He Zhao , Bertrand L. Chenard , Yang Gao , Bingsong Han , Xiao Shu He
- 申请人： George P. Luke , George D. Maynard , Scott Mitchell , Andrew Thurkauf , Linghong Xie , LuYan Zhang , Suoming Zhang , He Zhao , Bertrand L. Chenard , Yang Gao , Bingsong Han , Xiao Shu He
- 申请人地址： BM Hamilton
- 专利权人： Novartis International Pharmaceutical Ltd.
- 当前专利权人： Novartis International Pharmaceutical Ltd.
- 当前专利权人地址： BM Hamilton
- 代理机构： Edwards Angell Palmer & Dodge LLP
- 代理商 Peter F. Corless; Dwight D. Kim
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; A61K31/4164 ; A61K31/4178
摘要：
The invention provides packaged pharmaceutical preparations of Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula where the variables are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of the invention act bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory and immune system disorders.
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