Invention Grant
US08114880B2 Piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid MTP inhibiting compounds
有权
哌啶或哌嗪取代的四氢 - 萘-1-羧酸MTP抑制化合物
- Patent Title: Piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid MTP inhibiting compounds
- Patent Title (中): 哌啶或哌嗪取代的四氢 - 萘-1-羧酸MTP抑制化合物
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Application No.: US12446580Application Date: 2007-10-22
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Publication No.: US08114880B2Publication Date: 2012-02-14
- Inventor: Lieven Meerpoel , Joannes Theodorus Maria Linders , Libuse Jaroskova , Marcel Viellevoye , Leo Jacobus Jozef Backx , Didier Jean-Claude Berthelot , Guuske Frederike Busscher
- Applicant: Lieven Meerpoel , Joannes Theodorus Maria Linders , Libuse Jaroskova , Marcel Viellevoye , Leo Jacobus Jozef Backx , Didier Jean-Claude Berthelot , Guuske Frederike Busscher
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica N.V.
- Current Assignee: Janssen Pharmaceutica N.V.
- Current Assignee Address: BE Beerse
- Priority: EP06122817 20061024
- International Application: PCT/EP2007/061286 WO 20071022
- International Announcement: WO2008/049806 WO 20080502
- Main IPC: A61K31/4468
- IPC: A61K31/4468 ; A61K31/4965 ; A61K31/4545 ; C07D295/10 ; C07D401/14 ; C07D401/12 ; C07D211/58 ; A61P3/00
Abstract:
The present invention is concerned with novel piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
Public/Granted literature
- US20090325980A1 PIPERIDINE OR PIPERAZINE SUBSTITUTED TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID MTP INHIBITING COMPOUNDS Public/Granted day:2009-12-31
Information query
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