A universal device for securing a catheter on a patient includes a base which optionally has one or more locating elements for positioning or securing a catheter or catheter fitting of various shapes or sizes. The base optionally includes a recessed or flat receiving area defined by locating elements arranged in any configuration suitable to hold or receive a catheter or catheter fitting, e.g., in a tapering or V shaped formation. Additional locating elements may be positioned elsewhere on the base for receiving or holding a flange or wing of a catheter fitting and preventing its movement in various directions. The base optionally has an angled surface to maintain the desired angle for catheters or catheter fittings in a patient. A cover is removably or permanently connected to the base and may optionally have one or more top openings for receiving tabs or extensions of a catheter fitting.