An oral care instrument includes at least one oral care agent. In one embodiment, the oral care agent can be provided on one or more surfaces of the oral care instrument or included within cavities within the head or in one or more surfaces of a head. In other embodiment, the oral care agent can be provided in or on a thin slab subsequently bonded onto a surface, or applied as a stable coating. The oral care instrument can also be provided with a wear indicator. The oral care agents can be released during one use, during multiple uses, or throughout the life of the instrument. Water, oral secretions and/or chemicals within the mouth can activate the oral care agents.