Invention Grant
US08076513B2 Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
失效
制备N-异丁基-N-（2-羟基-3-氨基-4-苯基丁基） - 对硝基苯磺酰胺衍生物的方法
- Patent Title: Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
- Patent Title (中): 制备N-异丁基-N-（2-羟基-3-氨基-4-苯基丁基） - 对硝基苯磺酰胺衍生物的方法
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Application No.: US12597088Application Date: 2008-04-25
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Publication No.: US08076513B2Publication Date: 2011-12-13
- Inventor: Hartmut Burghard Zinser , Peter Hermann Hölzle
- Applicant: Hartmut Burghard Zinser , Peter Hermann Hölzle
- Applicant Address: IE Little Island
- Assignee: Tibotec Pharmaceuticals Ltd.
- Current Assignee: Tibotec Pharmaceuticals Ltd.
- Current Assignee Address: IE Little Island
- Priority: EP07107177 20070427
- International Application: PCT/EP2008/055042 WO 20080425
- International Announcement: WO2008/132154 WO 20081106
- Main IPC: C07C303/38
- IPC: C07C303/38 ; C07C311/18
Abstract:
A process for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives in which a (1-benzyl-2-hydroxy-3-isobutylamino-propyl)-carbamic acid derivative is reacted with a p-nitrophenylsulfonyl halide to provide the desired product in a high yield and degree of purity.
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