- 专利标题： Glucagon receptor antagonists, preparation and therapeutic uses
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申请号： US12093598申请日： 2006-11-10
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公开(公告)号： US08076374B2公开(公告)日： 2011-12-13
- 发明人: Mark Donald Chappell , Scott Eugene Conner , Philip Arthur Hipskind , Jason Eric Lamar , Guoxin Zhu
- 申请人： Mark Donald Chappell , Scott Eugene Conner , Philip Arthur Hipskind , Jason Eric Lamar , Guoxin Zhu
- 申请人地址： US IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： US IN Indianapolis
- 代理商 Dan L. Wood
- 国际申请： PCT/US2006/060769 WO 20061110
- 国际公布： WO2007/114855 WO 20071011
- 主分类号： A61K31/195
- IPC分类号： A61K31/195 ; C07C229/22 ; A61P3/10
摘要：
The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
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