发明授权
US08048912B2 Benzopyran derivatives having inhibitory activities against liver fibrosis and cirrhosis and their pharmaceutical uses
有权
具有对肝纤维化和肝硬化的抑制活性的苯并吡喃衍生物及其药物用途
- 专利标题： Benzopyran derivatives having inhibitory activities against liver fibrosis and cirrhosis and their pharmaceutical uses
- 专利标题（中）： 具有对肝纤维化和肝硬化的抑制活性的苯并吡喃衍生物及其药物用途
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申请号： US11794564申请日： 2005-06-15
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公开(公告)号： US08048912B2公开(公告)日： 2011-11-01
- 发明人: Young-Dae Gong , Jin-Soo Seo , Moon-Kook Jeon , Wie-Jong Kwak , Yong-Baik Cho , Nam Kyu Lee , Eun Ju Lee , Jung Bum Lee , Jun Won Lee , Sukho Lee , Mi-Sook Dong , Jeong-Ran Kim
- 申请人： Young-Dae Gong , Jin-Soo Seo , Moon-Kook Jeon , Wie-Jong Kwak , Yong-Baik Cho , Nam Kyu Lee , Eun Ju Lee , Jung Bum Lee , Jun Won Lee , Sukho Lee , Mi-Sook Dong , Jeong-Ran Kim
- 申请人地址： KR Gyeonggi-do KR Daejeon
- 专利权人： SK Chemicals Co., Ltd.,Korea Research Institute of Chemical Technology
- 当前专利权人： SK Chemicals Co., Ltd.,Korea Research Institute of Chemical Technology
- 当前专利权人地址： KR Gyeonggi-do KR Daejeon
- 代理机构： Frommer Lawrence & Haug LLP
- 代理商 Ronald R. Santucci
- 优先权： KR10-2004-0117707 20041231; KR10-2004-0117711 20041231
- 国际申请： PCT/KR2005/001833 WO 20050615
- 国际公布： WO2006/070984 WO 20060706
- 主分类号： A61K31/352
- IPC分类号： A61K31/352 ; C07D311/60 ; C07D311/70
摘要：
The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-β receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis, liver cirrhosis, pulmonary fibrosis, dermatosclerosis, glomerular fibrosis and the like; and a pharmaceutical use thereof.
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