An information handling system includes a processor that may perform issue queue virtual load/store instruction operations. The issue queue maintains load and store instructions with a real/virtual dependency flag. The issue queue provides storage resources for real and virtual load/store instructions. Real load/store instructions execute in a load store unit LSU. Virtual load/store instructions are pending execution in the LSU. The LSU may keep track of each virtual load/store instruction within the issue queue by thread, type, and pointer data. Provided that all dependencies are clear for a pending virtual load/store instruction, the LSU marks the pending virtual load/store instruction as real. The pending virtual load/store instruction may then issue to the LSU as a real load/store instruction.