发明授权
- 专利标题： Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
- 专利标题（中）： 提高包含二酮哌嗪和活性剂的微粒的药学性质的方法
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申请号： US11678046申请日： 2007-02-22
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公开(公告)号： US08039431B2公开(公告)日： 2011-10-18
- 发明人: Bryan R. Wilson , Marshall Grant
- 申请人： Bryan R. Wilson , Marshall Grant
- 申请人地址： US CA Valencia
- 专利权人： MannKind Corporation
- 当前专利权人： MannKind Corporation
- 当前专利权人地址： US CA Valencia
- 代理机构： K&L Gates LLP
- 代理商 Louis C. Cullman; Michelle Glasky Bergman
- 主分类号： A61K38/28
- IPC分类号： A61K38/28 ; G03G13/08
摘要：
Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
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