发明授权
- 专利标题： Signal amplification using a synthetic zymogen
- 专利标题（中）： 使用合成酶原的信号放大
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申请号： US10570075申请日： 2004-09-02
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公开(公告)号： US08039228B2公开(公告)日： 2011-10-18
- 发明人: Gerard J. Colpas , Shite Sebastian , Mitchell C. Sanders
- 申请人： Gerard J. Colpas , Shite Sebastian , Mitchell C. Sanders
- 申请人地址： US MA Worchester
- 专利权人： Expressive Constructs, Inc.
- 当前专利权人： Expressive Constructs, Inc.
- 当前专利权人地址： US MA Worchester
- 代理机构： Hamilton, Brook, Smith & Reynolds, P.C.
- 国际申请： PCT/US2004/028675 WO 20040902
- 国际公布： WO2005/021780 WO 20050310
- 主分类号： C12Q1/66
- IPC分类号： C12Q1/66
摘要：
Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a target for a protein produced by a microorganism. When the substrate is modified by a protein produced by a microorganism, the enzyme is activated. The zymogens can be used to amplify detection assays.
公开/授权文献
- US20070196881A1 Signal amplification using a synthetic zymogen 公开/授权日：2007-08-23
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