Invention Grant
US08017789B2 Process for production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-OXO-2-substituted-2,3-dihydro-1,2-benzisoxazol-6-yl]methoxy]phenyl]proprionate ester and intermediate for the process
有权
制备3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-氧代-2-取代-2,3-二氢-1,2-苯并异恶唑-6-基）甲氧基 ]苯基]丙酸酯和该方法的中间体
![Process for production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-OXO-2-substituted-2,3-dihydro-1,2-benzisoxazol-6-yl]methoxy]phenyl]proprionate ester and intermediate for the process](/docs/US/2011-09-13/US08017789B2/abs.jpg.600x600.jpg)
- Patent Title: Process for production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-OXO-2-substituted-2,3-dihydro-1,2-benzisoxazol-6-yl]methoxy]phenyl]proprionate ester and intermediate for the process
- Patent Title (中): 制备3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-氧代-2-取代-2,3-二氢-1,2-苯并异恶唑-6-基）甲氧基 ]苯基]丙酸酯和该方法的中间体
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Application No.: US12280098Application Date: 2007-02-19
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Publication No.: US08017789B2Publication Date: 2011-09-13
- Inventor: Kenji Yonezawa , Tamotsu Takamatsu , Naokatu Aoki , Tomohiro Hashimoto , Masahiro Takebayashi , Yoshiaki Suzuki , Yuji Oonishi
- Applicant: Kenji Yonezawa , Tamotsu Takamatsu , Naokatu Aoki , Tomohiro Hashimoto , Masahiro Takebayashi , Yoshiaki Suzuki , Yuji Oonishi
- Applicant Address: JP Tokyo
- Assignee: Toyama Chemical Co., Ltd.
- Current Assignee: Toyama Chemical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2006-043777 20060221; JP2006-121582 20060426; JP2006-121601 20060426
- International Application: PCT/JP2007/052953 WO 20070219
- International Announcement: WO2007/097279 WO 20070830
- Main IPC: C07D261/20
- IPC: C07D261/20 ; C07D311/02 ; C07C69/612
![Process for production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-OXO-2-substituted-2,3-dihydro-1,2-benzisoxazol-6-yl]methoxy]phenyl]proprionate ester and intermediate for the process](/abs-image/US/2011/09/13/US08017789B2/abs.jpg.150x150.jpg)
Abstract:
A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula wherein R5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; X represents a halogen atom, can be used as a method for safely and easily preparing 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid, which is useful as an antirheumatic agent, with a high yield.
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