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发明授权
US08017638B2 Isoxazole derivative and isothiazole derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 有权
具有抑制活性的异恶唑衍生物和异噻唑衍生物

Isoxazole derivative and isothiazole derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1
摘要：
Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is a group of the formula: —C(═O)NR4R5, (wherein R4 and R5 are each independently, hydrogen, optionally substituted alkyl or the like) or a group of the formula: —NR6C(═O)R7, (wherein R6 and R7 are each independently, hydrogen, optionally substituted alkyl or the like), X and Y are each independently —O— or the like, Z is a bond or the like, R2 is optionally substituted alkyl, optionally substituted alkenyl or the like, R3 is optionally substituted alkyl, optionally substituted alkenyl or the like.
摘要（中）：

公开了一种可用作11型β-羟基类固醇脱氢酶抑制剂的化合物。下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1是下式的基团：-C（= O）NR 4 R 5，（ 其中R 4和R 5各自独立地为氢，任选取代的烷基等）或下式的基团：-NR 6 C（= O）R 7，（其中R 6和R 7各自独立地为氢，任选取代的烷基等） X和Y各自独立地为-O-等，Z为键或类似物，R 2为任选取代的烷基，任选取代的烯基等，R 3为任选取代的烷基，任选取代的烯基等。

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