发明授权
- 专利标题： Process for the purification of gabapentin
- 专利标题（中）： 加巴喷丁的纯化方法
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申请号： US11722056申请日： 2005-12-15
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公开(公告)号： US07989658B2公开(公告)日： 2011-08-02
- 发明人: Roberto Giovanetti , Andrea Nicoli , Livius Cotarca
- 申请人： Roberto Giovanetti , Andrea Nicoli , Livius Cotarca
- 申请人地址： IT Bresso
- 专利权人： ZaCh System S.p.A.
- 当前专利权人： ZaCh System S.p.A.
- 当前专利权人地址： IT Bresso
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权： ITMI2004A2418 20041217
- 国际申请： PCT/EP2005/056817 WO 20051215
- 国际公布： WO2006/064041 WO 20060622
- 主分类号： C07C227/40
- IPC分类号： C07C227/40 ; C07C229/28
摘要：
The present invention relates to a process for the purification of gabapentin. The process relates to the addition of hydrochloric acid to an aqueous solution or suspension of gabapentin, before, during or after the concentration step of that solution, and the subsequent slurry of the gabapentin by the addition of an alcoholic solvent. The so obtained gabapentin has an high purity degree and, in particular, is characterized by a low content of lactam.
公开/授权文献
- US20090292138A1 PROCESS FOR THE PURIFICATION OF GABAPENTIN 公开/授权日：2009-11-26
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