Invention Grant
- Patent Title: Addition salts of angiotensin-converting enzyme inhibitors with no donor acids, a process for their preparation and pharmaceutical compositions containing them
- Patent Title (中): 不含供体酸的血管紧张素转换酶抑制剂的加成盐，其制备方法和含有它们的药物组合物
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Application No.: US12283928Application Date: 2008-09-17
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Publication No.: US07981920B2Publication Date: 2011-07-19
- Inventor: Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Jean-Gilles Parmentier , Alain Benoist , Tony Verbeuren , Alain Rupin , Christine Courchay , Serge Simonet
- Applicant: Guillaume De Nanteuil , Bernard Portevin , Philippe Gloanec , Jean-Gilles Parmentier , Alain Benoist , Tony Verbeuren , Alain Rupin , Christine Courchay , Serge Simonet
- Applicant Address: FR Suresnes Cedex
- Assignee: Les Laboratoires Servier
- Current Assignee: Les Laboratoires Servier
- Current Assignee Address: FR Suresnes Cedex
- Agency: Hueschen and Sage
- Priority: FR0706629 20070921
- Main IPC: A61K31/404
- IPC: A61K31/404 ; C07D209/12
Abstract:
Compounds of formula (I): (A)m·(B)n (I) wherein A represents an angiotensin-converting enzyme inhibitor compound containing at least one salt-forming basic function, B represents a compound containing at least one salt-forming acid function and at least one NO donor group, m represents the number of acid functions of B that have been converted to a salt and n represents the number of basic functions of A that have been converted to a salt, the bond or bonds between A and B being of the ionic type. Medicinal products containing the same which are useful in treating cardiovascular pathologies.
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