发明授权
US07977492B2 Crystal of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid
有权
得到3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并异恶唑-6-基）甲氧基]苯基]丙酸
![Crystal of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid](/docs/US/2011-07-12/US07977492B2/abs.jpg.600x600.jpg)
- 专利标题： Crystal of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid
- 专利标题（中）： 得到3- [5- [4-（环戊氧基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并异恶唑-6-基）甲氧基]苯基]丙酸
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申请号： US12302375申请日： 2007-05-25
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公开(公告)号： US07977492B2公开(公告)日： 2011-07-12
- 发明人: Kenji Yonezawa , Hironori Kotsubo , Yasutaka Baba , Yukie Tada
- 申请人： Kenji Yonezawa , Hironori Kotsubo , Yasutaka Baba , Yukie Tada
- 申请人地址： JP Tokyo
- 专利权人： Toyama Chemical Co., Ltd.
- 当前专利权人： Toyama Chemical Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权： JP2006-146220 20060526
- 国际申请： PCT/JP2007/060670 WO 20070525
- 国际公布： WO2007/138996 WO 20071206
- 主分类号： C07D261/20
- IPC分类号： C07D261/20
![Crystal of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid](/abs-image/US/2011/07/12/US07977492B2/abs.jpg.150x150.jpg)
摘要：
The crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.0, 16.0, 23.3, 23.7 and 26.3° and the crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.6, 23.1, 24.7, 25.6 and 26.0° on 2θ of diffraction angle in a powder X-ray diffraction pattern have a small specific volume, are hard to be charged with electricity, are easily handled and are useful for an active pharmaceutical ingredient of excellent anti-rheumatic agents.
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