发明授权
- 专利标题： FK 228 derivates as HDAC inhibitors
- 专利标题（中）： FK 228衍生物作为HDAC抑制剂
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申请号： US11916200申请日： 2006-06-02
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公开(公告)号： US07977304B2公开(公告)日： 2011-07-12
- 发明人: Arasu Ganesan , Graham Keith Packham , Alexander Yurek-George , Alexander Richard Liam Cecil
- 申请人： Arasu Ganesan , Graham Keith Packham , Alexander Yurek-George , Alexander Richard Liam Cecil
- 申请人地址： GB Southhampton
- 专利权人： University of Southampton Highfield
- 当前专利权人： University of Southampton Highfield
- 当前专利权人地址： GB Southhampton
- 代理机构： Saliwanchik, Lloyd & Eisenschenk
- 优先权： GB0511266.9 20050602
- 国际申请： PCT/GB2006/002022 WO 20060602
- 国际公布： WO2006/129105 WO 20061207
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61K31/542 ; C07K11/00 ; C07K11/02 ; C07K7/54
摘要：
Compounds which are FK228 analogues of the general formula (I) or (I′), isosteres thereof and pharmaceutically acceptable salts thereof are found to inhibit HDAC wherein R1, R2, R3 and R4 are the same or different and represent an amino acid side chain moiety and each R6 is the same or different and represents hydrogen or C1-C4 alkyl.
公开/授权文献
- US20090131390A1 FK 228 derivates as HDAC inhibitors 公开/授权日：2009-05-21
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