A method, system, and computer program product for target computer processor unit (CPU) determination during cache injection using I/O hub/chipset resources are provided. The method includes creating a cache injection indirection table on the input/output (I/O) hub or chipset. The cache injection indirection table includes fields for address or address range, CPU identifier, and cache type. In response to receiving an input/output (I/O) transaction, the hub/chipset reads the address in an address field of the I/O transaction, looks up the address in the cache injection indirection table, and injects the address and data of the I/O transaction to a target cache associated with a CPU as identified in the CPU identifier field when, in response to the look up, the address is present in the address field of the cache injection indirection table.