Invention Grant
- Patent Title: Antineoplastic agents targeted via glut transporters
- Patent Title (中): 通过谷氨酸转运蛋白靶向的抗肿瘤剂
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Application No.: US10560075Application Date: 2004-06-09
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Publication No.: US07943586B2Publication Date: 2011-05-17
- Inventor: Gang Zheng , Jerry D. Glickson , Britton Chance
- Applicant: Gang Zheng , Jerry D. Glickson , Britton Chance
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- International Application: PCT/US2004/018143 WO 20040609
- International Announcement: WO2004/110255 WO 20041223
- Main IPC: C07G3/00
- IPC: C07G3/00 ; C07G11/00 ; C07H15/00 ; C07H17/00 ; C07H5/06 ; A01N43/04 ; A61K31/70
Abstract:
The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The invention also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.
Public/Granted literature
- US20060171893A1 Antineoplastic agents targeted via glut transporters Public/Granted day:2006-08-03
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