An optical detection sensor detects presence or absence of a product within a fluid delivery medium. An emitter directs radiation into the fluid delivery medium and detectors detect transmitted light at a plurality of wavelengths. The output of each detector and combinations of outputs of multiple detectors are associated with at least one out-of-product threshold. In addition, a color ratio is established. A controller compares the detector outputs and combination outputs with the associated out-of-product threshold(s). If any of the thresholds are satisfied, the controller compares the color ratio with an associated out-of-product threshold to verify an out-of-product event has occurred and reduce errors due to batch-to-batch variation of the product. The sensor is able to determine presence or absence of a variety of products having different color, transparency or turbidity.