A multi-speed burst mode serializer/de-serializer (SerDes) is configurable and can operate in one of a plurality of operating modes. The plurality of operating modes correspond to the reception of signals from optical network units that operate at different nominal speeds. These various modes of operation can enable a single SerDes design to apply to a variety of speeds and network configurations (e.g., point-to-point or point-to-multipoint). In one example, the design can be initially configured for operation with a single ONT or a network of ONTs at a single speed, or can be dynamically configured during operation for use with a network of ONTs operating at different speeds.