发明授权
- 专利标题: Alternative process for the preparation of losartan
- 专利标题(中): 制备氯沙坦的替代方法
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申请号: US11990456申请日: 2005-12-21
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公开(公告)号: US07923566B2公开(公告)日: 2011-04-12
- 发明人: Arava Veera Reddy , Siripalli Udaya Bhaskara Rao , Chinnapillai Rajendiran , Venkateswarlu Jasti
- 申请人: Arava Veera Reddy , Siripalli Udaya Bhaskara Rao , Chinnapillai Rajendiran , Venkateswarlu Jasti
- 申请人地址: IN Hyderabad
- 专利权人: Suven Life Sciences Limited
- 当前专利权人: Suven Life Sciences Limited
- 当前专利权人地址: IN Hyderabad
- 代理机构: IpHorgan Ltd
- 优先权: IN1133/CHE/2005 20050816
- 国际申请: PCT/IN2005/000426 WO 20051221
- 国际公布: WO2007/020654 WO 20070222
- 主分类号: C07D403/10
- IPC分类号: C07D403/10 ; C07D257/00 ; C07F5/06
摘要:
The invention relates to an improved process for the preparation of Losartan. The process comprising reacting 2-n-butyl-4-chloro-5-formyl imidazole with 2-(4-bromomethyl) benzonitrile in the presence of a phase transfer catalyst and an alkali, and reducing the resulting cyano aldehyde to produce a cyano alcohol which is further reacted with sodium azide in N-methyl pyrrolidinone and a salt to produce Losartan.
公开/授权文献
- US20100190996A1 Process for the Preparation of Losartan 公开/授权日:2010-07-29
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