发明授权
- 专利标题： Modulators for amyloid beta
- 专利标题（中）： 淀粉样β的调节剂
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申请号： US12348370申请日： 2009-01-05
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公开(公告)号： US07923450B2公开(公告)日： 2011-04-12
- 发明人: Karlheinz Baumann , Alexander Flohr , Erwin Goetschi , Helmut Jacobsen , Synese Jolidon , Thomas Luebbers
- 申请人： Karlheinz Baumann , Alexander Flohr , Erwin Goetschi , Helmut Jacobsen , Synese Jolidon , Thomas Luebbers
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP08150173 20080111
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; A61K31/519 ; A61K31/4365 ; A61K31/426 ; C07D471/04 ; C07D401/10 ; C07D277/82
摘要：
The invention relates to compounds of formula wherein R1, R2, R3, R4, X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.
公开/授权文献
- US20090181965A1 MODULATORS FOR AMYLOID BETA 公开/授权日：2009-07-16
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