发明授权
US07915240B2 Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
失效
免疫调节化合物和与炎症细胞因子过度生成有关的疾病的治疗
- 专利标题: Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
- 专利标题(中): 免疫调节化合物和与炎症细胞因子过度生成有关的疾病的治疗
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申请号: US12279845申请日: 2007-03-09
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公开(公告)号: US07915240B2公开(公告)日: 2011-03-29
- 发明人: Jacques Bauer , Carlo Chiavaroli , Stéphane Moutel
- 申请人: Jacques Bauer , Carlo Chiavaroli , Stéphane Moutel
- 申请人地址: CH Meyrin
- 专利权人: OM Pharma
- 当前专利权人: OM Pharma
- 当前专利权人地址: CH Meyrin
- 代理机构: Law Offices of Albert Wai-Kit Chen, PLLC
- 优先权: WOPCT/IB2006/050748 20060309
- 国际申请: PCT/IB2007/000567 WO 20070309
- 国际公布: WO2007/102081 WO 20070913
- 主分类号: A01N57/00
- IPC分类号: A01N57/00 ; A61K31/66
摘要:
Method of using immunomodulatory compounds for treating diseases related to an overproduction of inflammatory cytokines, including diseases selected from asthma, atopic dermatitis, allergic rhinitis, prostatitis, inflammatory bowel disease, diabetes, and rhumatoid arthritis, the compounds being of general formula (I): wherein: m and n, independently from each other, are an integer ranging from 1 to 4, X and Y represent —COOH, —O—P(O)(OH)2, —O—SO2(OH), —NH2, —OH, —CONH(CH2)n1—NH2, —CO—NH—CH(COOH)—(CH2)n1—COOH, —CO—NH—CH(COOH)—(CH2)n1—NH2, —O—CO—(CH2)n1—NH2, —O—CO—(CH2)n1—CHOH—CH2OH, —O—CO—(CH2)n1—OH, —O—CO—(CH2)n1—COOH, —O—CO—(CH2)n1—CHO, —O—CO—(CH2)n1—NH—CO—(CH2)n2—COOH, R1 and R2 each designate an acyl group derived from a saturated or unsaturated, straight- or branched-chain carboxylic acid having from 2 to 18 carbon atoms, which is unsubstituted or bears one to three substituents selected among hydroxyl, dihydroxyphosphoryloxy, alkyl of 2 to 18 carbon atoms, alkoxy of 2 to 18 carbon atoms, acyloxy of 2 to 18 carbon atoms in the acyl moiety, amino, acylamino.
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