发明授权
- 专利标题： DNA enzymes
- 专利标题（中）： DNA酶
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申请号： US10504616申请日： 2003-02-11
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公开(公告)号： US07910710B2公开(公告)日： 2011-03-22
- 发明人: Yingfu Li , John Brennan , Shirley Mei , Zhongjie Liu
- 申请人： Yingfu Li , John Brennan , Shirley Mei , Zhongjie Liu
- 申请人地址： CA Hamilton, Ontario
- 专利权人： McMaster University
- 当前专利权人： McMaster University
- 当前专利权人地址： CA Hamilton, Ontario
- 代理机构： Gowling Lafleur Henderson LLP
- 国际申请： PCT/CA03/00198 WO 20030211
- 国际公布： WO03/068963 WO 20030821
- 主分类号： C07H21/02
- IPC分类号： C07H21/02
摘要：
Methods for the selection of novel signaling allosteric DNA enzymes are provided. In particular, fluorescent signaling allosteric DNA enzymes are described. The selection system is based on the cleavage of an ribonucleotide flanked by a fluorophore modified nucleotide and a quencher modified oligonucleotide. Both cis-acting and trans-acting allosteric DNA enzymes are identified, as well as aptamer/DNA enzyme conjugates.
公开/授权文献
- US20060292561A1 Dna enzymes 公开/授权日：2006-12-28
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