发明授权
US07910598B2 Phenylaminopyrimidine derivatives as inhibitors of BCR-ABL kinase
有权
苯基氨基嘧啶衍生物作为BCR-ABL激酶的抑制剂
- 专利标题： Phenylaminopyrimidine derivatives as inhibitors of BCR-ABL kinase
- 专利标题（中）： 苯基氨基嘧啶衍生物作为BCR-ABL激酶的抑制剂
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申请号： US11714565申请日： 2007-03-05
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公开(公告)号： US07910598B2公开(公告)日： 2011-03-22
- 发明人: Amala kishan Kompella , Bhujanga rao Adibhatla Kali Satya , Sreenivas Rachakonda , Khadgapathi Podili , Nannapaneni Venkaiah Chowdary
- 申请人： Amala kishan Kompella , Bhujanga rao Adibhatla Kali Satya , Sreenivas Rachakonda , Khadgapathi Podili , Nannapaneni Venkaiah Chowdary
- 申请人地址： IN Hyderabad
- 专利权人： Natco Pharma Limited
- 当前专利权人： Natco Pharma Limited
- 当前专利权人地址： IN Hyderabad
- 代理机构： Merchant & Gould P.C.
- 优先权： IN908/CHE/2004 20040909
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D401/14 ; A61K31/506
摘要：
The present invention relates to novel intermediates useful for the preparation of novel phenylaminopyrimidine derivatives, novel phenylaminopyrimidine derivatives. Pharmaceutical composition containing the novel phenylaminopyrimidine derivatives and processes for their preparation. The invention particularly relates to novel Phenyl pyrimidine amine derivatives of the general formula (I). The novel compounds of the formula 1 can be used in the therapy of Chronic Myeloid Leukemia (CML). Since the IC50; 191 values of these molecules are in the range 0.1 to 10.0 nm, these novel compounds are potentially useful for the treatment of CML.
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