发明授权
- 专利标题： Oligonucleotides which inhibit expression of the OB-RGRP protein
- 专利标题（中）： 抑制OB-RGRP蛋白表达的寡核苷酸
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申请号： US10774721申请日： 2004-02-09
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公开(公告)号： US07884084B2公开(公告)日： 2011-02-08
- 发明人: Ralf Jockers , Cyril Couturier , Eugen Uhlmann
- 申请人： Ralf Jockers , Cyril Couturier , Eugen Uhlmann
- 申请人地址： FR Antony FR Paris FR Paris
- 专利权人： Aventis Pharma S.A.,Institut National de la Sante Et de la Recherche Medicale,Centre National de la Rechercher Scientifique
- 当前专利权人： Aventis Pharma S.A.,Institut National de la Sante Et de la Recherche Medicale,Centre National de la Rechercher Scientifique
- 当前专利权人地址： FR Antony FR Paris FR Paris
- 优先权： FR0301543 20030210
- 主分类号： C12N15/11
- IPC分类号： C12N15/11
摘要：
The present application relates to antisense oligonucleotides which inhibit expression of the OB-RGRP protein and to uses thereof for preventing and/or treating leptin-related pathological conditions.It also relates to a method for detecting compounds which modify the interaction between proteins of the OB-RGRP family and the leptin receptor. This detection may be carried out by measuring the energy transfer between fusion proteins composed of these proteins and of energy-donor and -acceptor proteins.
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