发明授权
US07847100B2 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
有权
可用作治疗阿尔茨海默病的β-分泌酶抑制剂的1,3,5-取代苯基衍生物化合物
- 专利标题： 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
- 专利标题（中）： 可用作治疗阿尔茨海默病的β-分泌酶抑制剂的1,3,5-取代苯基衍生物化合物
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申请号： US11578559申请日： 2005-04-15
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公开(公告)号： US07847100B2公开(公告)日： 2010-12-07
- 发明人: James C. Barrow , Georgia B. McGaughey , Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , Shaun R. Stauffer , Craig A. Coburn
- 申请人： James C. Barrow , Georgia B. McGaughey , Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , Shaun R. Stauffer , Craig A. Coburn
- 申请人地址： US NJ Rahway
- 专利权人： Merck, Sharp & Dohme, Inc.
- 当前专利权人： Merck, Sharp & Dohme, Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Keith D. MacMillan; John C. Todaro
- 国际申请： PCT/US2005/012973 WO 20050415
- 国际公布： WO2005/103020 WO 20051103
- 主分类号： A61K31/4245
- IPC分类号： A61K31/4245 ; C07D271/10 ; C07D271/06
摘要：
The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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