A method and systems for capturing digital intra-oral images, while automatically determining a location of an intra-oral sensor placed within a mouth of a patient, is disclosed. A spatial frame-of-reference is established with respect to teeth within the mouth of the patient. An intra-oral digital imaging sensor is placed within the mouth of the patient adjacent to at least one tooth within the mouth that is to be imaged using the intra-oral sensor. Spatial location information is automatically generated such that the spatial location information defines how the intra-oral sensor is placed with respect to the spatial frame-of-reference. A digital image of at least one tooth is acquired using the intra-oral sensor and the spatial location information is automatically associated with the acquired digital image. The associated spatial location information may be used to automatically correlate the acquired image to a tooth or teeth within the mouth and/or to automatically orient the acquired image for display.