A method for manufacturing a ceramic multi-layered substrate includes a first step of forming a green ceramic laminate including a plurality of stacked green ceramic base layers, a second step of firing the green ceramic laminate to sinter the green ceramic layers, and a third step of separating the sintered ceramic laminate formed by firing the green ceramic laminate into a ceramic multi-layered substrate. The green ceramic base layers stacked in the first step include a separation pattern formed along separation lines, the separation pattern disappearing during firing. In the third step, the sintered ceramic laminate is separated into a plurality of ceramic multi-layered substrates separated through a cavity formed by the disappearance of the separation pattern during the firing in the second step.