发明授权
- 专利标题： Aminoamides as orexin antagonists
- 专利标题（中）： 氨基酰胺作为食欲肽拮抗剂
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申请号： US12037975申请日： 2008-02-27
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公开(公告)号： US07829563B2公开(公告)日： 2010-11-09
- 发明人: Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- 申请人： Luca Gobbi , Henner Knust , Parichehr Malherbe , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP07103521 20070305
- 主分类号： A61K31/50
- IPC分类号： A61K31/50 ; A61K31/501 ; A61K31/497 ; A01N43/54 ; C07D239/42 ; C07D401/04 ; A01N43/40 ; A61K31/435 ; A01N43/78 ; A61K31/425 ; A01N43/50 ; A61K31/415 ; A01N43/56 ; A01N43/08 ; A61K31/34 ; C07D279/00 ; C07D285/00 ; C07D401/00 ; C07D421/00 ; C07D419/00 ; C07D277/04 ; C07D277/08 ; C07D409/00 ; C07D335/00 ; C07D333/02 ; C07D321/00 ; C07D307/00 ; C07D317/00 ; C07D323/02
摘要：
The present invention relates to compounds of formula I wherein Ar1, Ar2, Ar3, n, and R1 to R8 are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved, like sleep disorders.
公开/授权文献
- US20080221166A1 AMINOAMIDES AS OREXIN ANTAGONISTS 公开/授权日：2008-09-11
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