发明授权
US07807455B2 Method to confer cell culture replication activity to different Hepatitis C virus isolates
失效
赋予不同丙型肝炎病毒分离株细胞培养复制活性的方法
- 专利标题: Method to confer cell culture replication activity to different Hepatitis C virus isolates
- 专利标题(中): 赋予不同丙型肝炎病毒分离株细胞培养复制活性的方法
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申请号: US10543633申请日: 2004-02-09
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公开(公告)号: US07807455B2公开(公告)日: 2010-10-05
- 发明人: Jay Grobler , Osvaldo Flores , Eric J. Markel
- 申请人: Jay Grobler , Osvaldo Flores , Eric J. Markel
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理商 Melissa B. Wenk; Sheldon O. Heber
- 国际申请: PCT/US2004/003726 WO 20040209
- 国际公布: WO2004/074507 WO 20040902
- 主分类号: C12N15/00
- IPC分类号: C12N15/00 ; C12Q1/68 ; C12Q1/70 ; C07H21/00
摘要:
The present invention features methods for producing HCV replicons using HCV encoding sequences from different isolates. The featured methods are based on the discovered importance of NS3 amino acid position 470 in conferring cell culture replication activity to different HCV isolates.
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